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KMID : 0043319900130030265
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Archives of Pharmacal Research
1990 Volume.13 No. 3 p.265 ~ p.268
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Effects of Lignans on Hepatic Drug-Metabolizing Enzymes
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Shin KH
Woo WS/Lee JY/Han YB
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Abstract
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The effects of lignans, related to macelignan, on hepatic microsomal drug-metabolizing enzyme (DME) activity were evaluated to elucidate the structure-activity relationship in mice and rats. The compounds carrying the methylenedioxyphenyl nucleus were found to be the most potent among compounds tested; which not only produced a marked inhibition of DME with a single dose but a significant induction with repeated treatments. Lack of the methylenedioxy group caused marked decrease in the activity, implying that a methylenedioxy group is essential and of major importance eliciting DME modifying activity.
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KEYWORD
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